NCT04151095已完成不适用
Examining The Effect of Blood Flow Restricted Aerobic Training on Citrate Synthase Activity in Young Healthy Adults
Brendon Gurd, PhD2 个研究点 分布在 1 个国家目标入组 19 人开始时间: 2019年5月6日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Citrate Synthase
研究概览
简要总结
This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase. Participants will be randomized to either a blood flow restricted or non-blood flow restricted exercise training group. Both groups will complete seven, 30-minute exercise sessions over a 14-day period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Allocation concealment, assessor blinding
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •3 hours of physical activity per week
- •No previous cycling training
- •No concurrent involvement in another training program
- •Body mass index < 30 kg/m2
排除标准
- •Presence of cardiovascular disease
- •Presence of metabolic disease
- •Taking regular oral medication
- •Current smoker
结局指标
主要结局
Citrate Synthase
时间窗: 3 days prior to start of exercise training and 3 days after completing exercise training
Fold change in citrate synthase maximal activity
次要结局
- Maximal oxygen consumption (VO2peak)(3 days before training to 3 days after training)
- Transcription factor A, mitochondrial (TFAM)(3 days before training to 3 days after training)
- Revolutions per minute (RPM)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
- Blood [lactate](During all exercise sessions at 10 and 30 minutes)
- Cytochrome c oxidase (COX)(3 days before training to 3 days after training)
- Electromyography (EMG)(Throughout each of the 7, 30-minute exercise sessions)
- Near-infrared spectroscopy (NIRS)(Throughout each of the 7, 30-minute exercise sessions)
- Nuclear respiratory factor, 1 (NRF1)(3 days before training to 3 days after training)
- Rating of perceived exertion (RPE)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
- Nuclear Factor, Erythroid 2 Like 2 (NFE2L2)(3 days before training to 3 days after training)
- Heart rate (HR)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
研究者
Brendon Gurd, PhD
Associate Professor
Queen's University
研究点 (2)
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