NCT02303691已完成不适用
Neural Dimensions of Attention Bias Modification for Transdiagnostic Anxiety
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- CAPS--Hypervigilance item
研究概览
简要总结
This project seeks to identify neural mechanisms underlying the tendency for anxious individuals to pay more attention to threatening information than to other types of information. A computerized treatment designed to train individuals to reduce their attention towards threat will be tested, with a focus on understanding the aspects of brain function that predict response to the treatment. This work could ultimately lead to the ability to treat anxiety more effectively by directly targeting the aspects of brain function that are altered in a given patient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants will:
- •be between the ages of 18 and 55 years,
- •score >45 on the Spielberger State-Trait Anxiety Inventory-trait form.
- •score >=75th percentile on the World Health Organization Disability Assessment Schedule 2.0
排除标准
- •Current medication or Cognitive-Behavioral Therapy for anxiety or depression;
- •Failure to meet standard Magnetic Resonance Imaging (MRI) inclusion criteria: those who have cardiac pacemakers, neural pacemakers, surgical clips in the brain or blood vessels, surgically implanted metal plates, screws or pins, cochlear implants, Intrauterine Devices, metal braces, or other metal objects in their body, especially in the eye. If the subject has any metal or implants in the body they must be deemed safe by the MRI Research Center's safety screening procedure prior to enrollment. Dental fillings do not present a problem. Plastic or removable dental appliances do not require exclusion. Pregnancy, determined by pregnancy tests on females.
- •currently suicidal or at risk for harm to self or others,
- •visual disturbance (<20/40 as per the Snellen test, corrective lenses allowed)
- •<6th grade reading level as per the Wide Range Achievement Test
- •presence of bipolar, psychotic, autism spectrum, substance dependence, or primary depressive disorder
- •positive urine drug test
研究组 & 干预措施
Computerized Neutral Training
Sham Comparator
干预措施: Neutral Training (Behavioral)
Computerized Attention Bias Modification
Experimental
干预措施: Attention Bias Modification (Behavioral)
结局指标
主要结局
CAPS--Hypervigilance item
时间窗: 1 month
次要结局
- Mood and Anxiety Symptoms Questionnaire(1 month)
- Mini International Neuropsychiatric Interview (MINI)(1 month)
- Attentional bias towards threat (Performance-based assessment of attentional bias towards threat based on reaction times and eye tracking)(immediate)
- Liebowitz Social Anxiety Scale(1 month)
- World Health Organization Disability Assessment Scale (WHODAS)(1 month)
- Speilberger State-Trait Anxiety Inventory(1 month)
- Beck Anxiety Inventory(1 month)
- Penn State Worry Questionnaire(1 month)
研究者
Rebecca Price
PhD
University of Pittsburgh
研究点 (2)
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