NCT06138951已完成不适用
Dose Response Effect of Endurance Exercise on Protein Requirements of Endurance Athletes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Phenylalanine excretion
研究概览
简要总结
Study will investigate the impact of training volume on protein metabolism to estimate the impact on daily protein requirements of endurance athletes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy, male, endurance-trained participants who regularly run more than 40 km/week or perform endurance exercise for more than 4.5 hours/week
- •Participants who have a self-reported 5-km run time of ≤23 min
- •Participants who are categorized as at least "very good" based on a study by Shvartz & Reibold (Aviat Space Environ Med. 1990 Jan;61(1):3-11), in which VO2peak is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y)
- •Ability to complete the 16-km familiarization run on Session 2
- •Aged 18-40 years old
排除标准
- •- Inability to meet health and physical activity guidelines according to the PAR-Q+.
- •Female: hormonal fluctuations associated with the menstrual cycle have been reported to alter protein metabolism during exercise and may influence specific amino acid requirements at rest; as such, the present study will test the effect of endurance exercise on protein requirements in males only to ensure a stable hormonal environment and to increase the homogeneity of the physiological response. (NOTE: we plan to test females in a future trial based off of the results obtained herein)
- •Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
- •Regular tobacco use
- •Illicit drug use (e.g. growth hormone, testosterone, etc.)
结局指标
主要结局
Phenylalanine excretion
时间窗: 8 hours
Excretion of 13CO2 in the breath will be used to estimate the impact of exercise on daily protein requirements. This outcome will include the enrichment of 13CO2 in exhaled breath after the ingestion of \[13C\]phenylalanine tracer and the production of CO2 determined by indirect calorimetry at rest or after exercise.
次要结局
- Phenylalanine flux(8 hours)
- Phenylalanine oxidation(8 hours)
研究者
Daniel Moore
Associate Professor
University of Toronto
研究点 (2)
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