CTIS2023-504322-19-00招募中1 期
Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage - ZKSJ0153
Friedrich Schiller Universitaet Jena0 个研究点目标入组 710 人开始时间: 2023年6月5日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 710
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •= 18 years, Invasive ventilation expected for = 48 hours from time of randomization, PCR HSV-1 detection in BAL (= 105 copies/ml), Pneumonia (community or healthcare acquired incl. ventilator-associated pneumonia), Written declaration of consent by the patient or legal representative.
排除标准
- •History of hypersensitivity to acyclovir or valacyclovir or other components of the investigational product, Pregnancy/Lactation, Simultaneous participation in another interventional clinical trial, Decision to withhold life-sustaining therapies, Use of a virostatic agent (i.v. or p. os) with activity against herpes simplex (valacyclovir, famciclovir/penciclovir, brivudine, cidofovir, foscarnet) for therapeutic or prophylactic reasons at the time of randomization, Solid organ transplantation, stem cell transplantation, Neutropenia (absolute neutrophil count <1500/µl (<1.5 × 109 /l), Previous study participation in HerpMV
研究者
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