The Role of Left Prefrontal Transcranial Magnetic Stimulation in Episodic Migraine Prophylaxis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 主要终点
- Migraine attack frequency
研究概览
简要总结
The aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rTMS) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical treatment.
A group received 5 rTMS sessions, delivered over one week. Each rTMS session consisted of a single train of 900 total pulses over 3 minutes duration given at 5-Hz frequency and 100% motor threshold intensity and the placebo group received rTMS with the same stimulation frequency at a fixed intensity of 50% of the machine output
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cases diagnosed as episodic migraine with or without aura according to the ICHD 3rd edition
- •With a headache frequency of 4-14 per month for the last six months
- •Patients who had either an unsatisfactory response, declined or were intolerant to at least two prophylactic medications.
排除标准
- •Patients with past family history of seizures
- •Other chronic pain disorders
- •Severe depression (Beck Depression Inventory of 30 or more)
- •Other significant neurologic or psychiatric diagnosis including substance misuse
- •Metal implants in the head
- •Pregnant or breastfeeding ladies
- •Prior experience with TMS
研究组 & 干预措施
Receiving repetitive transcranial magnetic stimulation (rTMS)
This group received 5 rTMS sessions, delivered over one week over the left dorsolateral prefrontal cortex (LDLPFC ) at 5-Hz frequency and 100% motor threshold intensity.
干预措施: repetitive transcranial magnetic stimulation (rTMS) 100% motor threshold (Device)
Group receiving placebo rTMS
This group received Placebo rTMS was given with the same stimulation frequency at a fixed intensity of 50% of the machine output
干预措施: repetitive transcranial magnetic stimulation (rTMS) 50% motor threshold (Device)
结局指标
主要结局
Migraine attack frequency
时间窗: 2 months
The primary outcome measure was defined as the reduction of number of migraine attacks by at least 50% after rTMS sessions.
次要结局
- Functional disability(2 months)
- Use of abortive pills(2 months)
- Migraine days(2 months)
- Migraine attack severity(2 months)
研究者
Tamer Emara
Assistant professor of neurology
Ain Shams University