Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Drop Out
研究概览
简要总结
This project assessed the feasibility of transcranial alternating current stimulation in the gamma band to lower beta-amyloid load and improve memory performance.
详细描述
Thirteen individuals with aMCI received eight 60-minute sessions of 40-Hz (gamma) transcranial alternating current stimulation (tACS) in a single-arm design. Outcome measures were assessed pre- and post-intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •English speaking
- •Grade 12 or more education
- •Normal or corrected to normal vision and hearing
- •Ability to complete cognitive tasks
- •Ability to cooperate and comply with all study procedures
- •Ability to tolerate tACS
- •Self-reported memory complaint
- •Diagnosed with mild cognitive impairment
- •Amyloid positive
排除标准
- •Neurological or psychiatric disorders other than mild cognitive impairment
- •Receiving investigational medications or have participated in a trial with investigational medications within last 30 days
- •Family history of epilepsy
- •Implanted electronic devices (e.g., pacemaker)
- •Prior head trauma
- •Taking cholinesterase inhibitory, memantine, or psychotropic medication
- •Taking anti-depressants or anti-anxiety medication
- •Color blind
- •Substance abuse
- •Macular degeneration
- •Amblyopia (lazy eye)
- •Strabismus (crossed eyes)
结局指标
主要结局
Drop Out
时间窗: post-tACS, up to 1 month
Drop out rate will be assessed as the number of participants who withdraw or are withdrawn from the study.
Side Effects
时间窗: Average of all post-tACS sessions, up to 1 month
Side effects were measured on a scale from 0 (not noticable) to 10 (not tolerable): headache, neck pain, scalp pain, tingling, itching, burning sensation, increased sleepiness, trouble concentrating, acute mood change, and phosphenes. Average rating across all measures reported as indicator of side effects.
次要结局
- Change in Tau(pre-tACS (baseline), post-tACS (after one month of treatment))
- Beta Amyloid Load Change(pre-tACS (baseline) and post-tACS (1 month))
- Memory: Recall Change(pre-tACS (baseline), post-tACS (after one month of treatment))
- Memory: Fluency Change(pre-tACS (baseline), post-tACS (after one month of treatment))
- Memory: Paired Associates Change(pre-tACS (baseline), post-tACS (after one month of treatment))