NCT01419392Unknown4 期
Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages: a Randomized Clinical Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Uterine arteries blood flow
研究概览
简要总结
The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 18-35 years
- •Three or more recurrent miscarriages before the 24th week of gestation with no apparent cause for their previous losses
- •Three or more months have elapsed since the last abortion
- •Postmenstrual period
- •No other therapy allowed during our treatment course
排除标准
- •Concomitant use of organic nitrites, or nitrates
- •Severe hepatic, renal, or cardiovascular impairment
- •History of stroke or myocardial infarction
- •Patients with retinitis pigmentosa.
研究组 & 干预措施
Sildenafil citrate
Experimental
干预措施: Sildenafil citrate (Drug)
placebo
Placebo Comparator
干预措施: matching placebo (Drug)
结局指标
主要结局
Uterine arteries blood flow
时间窗: 21 days
Uterine arteries blood flow assessed by Doppler U/S by measuring Systolic / diastolic ratio, pulsatility index and resistance index
次要结局
- Nitric oxide serum level as a marked of oxidative stress(21 days)
- Total antioxidant capacity serum level as a marker of oxidative stress(21 days)
研究者
Tamer El-Refaie
Lecturer of Obstetrics and Gynecology
Ain Shams University
研究点 (1)
Loading locations...
相似试验
Unknown
4 期
Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial DevelopmentIVF FailureNCT03044561Ain Shams University80
Unknown
不适用
Sildenafil Citrate Therapy for OligohydramniosPregnancy ComplicationNCT02372487Al Hayat National Hospital184
尚未招募
2 期
Sildenafil citrate to improve maternal and neonatal outcomes in low-resource settings: a randomized feasibility trialNeonatal DiseasesPregnancy and ChildbirthPACTR202303797356166niversity of Alabama at Birmingman500
招募中
2 期
The Effect of Sildenafil Citrate on Frozen Embryo Transfer CyclesIVFNCT05951413Beni-Suef University110
终止
2 期
Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial)Hypertension, PulmonaryDiseases of Mitral ValveNCT02435303Asan Medical Center2