NCT02621749终止不适用
Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound
研究概览
简要总结
The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 yrs.
- •Signed IC
排除标准
- •Heart disease (PFO, ASD, VSD, severe valvular disease)
- •Atrial fibrillation
- •Cerebrovascular pathology
- •Missing temporal bone window
- •Allergy to plastic contained in the investigative device (transcranial Doppler)
- •Chronic kidney disease
- •Pregnancy
- •Participation in another study
结局指标
主要结局
Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound
时间窗: During hemodialysis therapy
次要结局
未报告次要终点
研究者
研究点 (2)
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