NCT02570230已完成4 期
Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Time to first trigger of morphine
研究概览
简要总结
Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status 1-3
- •elective thoracotomy
- •can operate patient-controlled analgesia (PCA) machine
排除标准
- •patient with history of
- •allergy to morphine or ketamine
- •contraindicate to ketamine
- •remain intubated in the postoperative period
研究组 & 干预措施
Control
Placebo Comparator
NSS infusion
干预措施: NSS (Other)
Ketamine
Experimental
Ketamine 0.2 mg/kg/hr intravenous infusion
干预措施: Ketamine (Drug)
结局指标
主要结局
Time to first trigger of morphine
时间窗: 24 hours
Time to first trigger of morphine
次要结局
- 24-hr morphine consumption(24 hours)
- NRS score at 6, 24 hours(24 hours)
- Incidence of nausea and vomiting(24 hours)
研究者
Sirilak Suksompong
Associate Professor
Mahidol University
研究点 (1)
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