跳至主要内容
临床试验/NCT04946331
NCT04946331Unknown不适用

Comparison of Lung Function Based on Electrical Impedance Tomography and CT Lung Volume in Patients With Rib Fractures

National Taiwan University Hospital2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2021年6月8日最近更新:
适应症

试验速览

阶段
不适用
入组人数
60
试验地点
2
主要终点
2nd EIT test

研究概览

简要总结

Our research uses the electrical impedance tomography system (EIT), which can use the applied current and measurement voltage through the body surface electrode group, and use the reconstruction algorithm to construct an image imaging system that exceeds the cross-sectional, which can provide images of the internal physiological changes of the chest contour, in order to quantify the changes in lung function caused by rib fractures.

详细描述

Rib fractures are one of the most common injuries following blunt trauma, occurring in approximately 10% of all trauma patients. Rib fracture injuries extend across a broad spectrum of severity from a single fractured rib which may be sustained in a fall or sporting injury, to multiple fractured ribs resulting in a flail chest with paradoxical chest wall movement and respiratory failure.

Flail chest, which defines multiple adjacent ribs broken in multiple places, is the most serious chest injury, and it damages the chest wall integrity and causes "paradoxical motion" from the detachment of a segment from the rest of the chest wall. Surgical management of rib fractures has received increasing attention in recent years with the development of new fixation techniques.

The mortality rate is 4% to 20%. Flail chest (FC), which defines multiple adjacent ribs broken in multiple places, is the most serious chest injury, and it damages the chest wall integrity and causes "paradoxical motion" from the detachment of a segment from the rest of the chest wall. Pulmonary contusion (PC) is the most common chest injury. These conditions frequently exist at the same time. Currently, a deeper understanding of FC pathophysiology exists, and its management has evolved substantially over the past 6 decades.

The earliest treatment for FC was surgery. With the increasing technological advancements available in the intensive care unit, conservative management, based on mechanical ventilation supplemented with intensive pain control, has become more common. Using positive airway pressure to reduce the asynchronous movement of FC could avoid surgical risks and postoperative complications. Conservative treatment has been administered frequently in previous years.

A growing number of researchers have found that surgery for FC could reduce the duration of mechanical ventilation, the ICU length of stay, the hospital length of stay, the incidence of pneumonia and tracheostomy, and mortality. Additional benefits included decreased doses of analgesic and sedative drugs and avoidance of thoracic deformity, and patients could return to previous employment quicker than could those treated conservatively.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Over 20 years old
  • At least 3 rib fractures due to thoracic trauma, or in compliance with the definition of flail chest.
  • Consciousness Coma Index (GSC) 14 points or above

排除标准

  • Consciousness coma index (GSC) less than 14 points
  • Have received thoracic surgery (including patients with partial and full lobes)
  • Patients with pacemakers
  • Spinal lesions or fractures of spinal instability
  • Vulnerable population
  • Patients who need to remove more than one lung lobe during surgery

结局指标

主要结局

2nd EIT test

时间窗: In 2nd weeks

Pulmonary function test with EIT after surgical / (no surgical ) in 2nd weeks

1st EIT test

时间窗: In 72 hours

Pulmonary function test with EIT before surgical in 72 hrs

3rd EIT test

时间窗: In 12th weeks

Pulmonary function test with EIT after surgical / (no surgical ) in 12th weeks

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

Loading locations...

相似试验