QLESP Block for Postoperative Analgesia in Hip Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- The cumulative opioid consumption
研究概览
简要总结
Total hip arthroplasty (THA) is a common surgical procedure aiming to improve mobility and quality of life in patients suffering from hip pain. Regional analgesia techniques are critical components of an optimal multimodal analgesia technique for THA, as they have been shown to improve pain relief as well as reduce opioid requirements. Ultrasound-guided suprainguinal fascia iliaca (SFI) block has been recommended as a reliable analgesic option for THA. However, SFI block may lead to decreased motor strength of the surgical limb thereby hindering postoperative mobilization. Recently, our group has developed a novel transmuscular quadratus lumborum and modified erector spinae plane (QLESP) block, which is characterized by simple operation, high efficiency, and wide dermatomal coverage of sensory block. In this randomized trial, we aimed to compare ultrasound-guided QLESP with SFI block as a component of non-opioid analgesic regimen in patients undergoing THA. The primary outcome of the study was postoperative sufentanil consumption within the initial 24-h postoperative period after THA. The secondary objectives were to compare pain scores, postoperative quadriceps strength, the time to first rescue analgesia, opioid-related adverse effects, time to ambulation, and the time to hospital discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-65 yrs
- •American Society of Anesthesiologists classification 1-3
- •Body mass index between 20 and 35 (kg/m2)
- •Undergo elective primary unilateral THA via a posterolateral approach
- •Informed consent
排除标准
- •A known allergy to the drugs being used
- •Pre-existing neuropsychiatric disorders or language barrier
- •Analgesics intake, history of substance abuse
- •Contraindications to peripheral nerve block
- •Acute cerebrovascular disease
- •Severe liver failure
结局指标
主要结局
The cumulative opioid consumption
时间窗: At 24 postoperative hours
次要结局
- Postoperative hospital length of stay(Up to 6 weeks)
- Adverse events(Postoperative 48 hours)
- The time to first rescue analgesia(Within postoperative 48 hours)
- Quadriceps strength(At 1, 6, 12, 24, and 48 hours after the surgery)
- The pain scores determined by the numeric rating scale (NRS, 0-10)(At 1, 6, 12, 24, and 48 hours after the surgery)
- The Time to Ambulation(Postoperative 48 hours)
研究者
Xi Wu
Doctor
Huazhong University of Science and Technology