Treatment of Postoperative Pain After Total Hip Arthroplasty Using Intravenous Lidocaine Infusion

Phase 1

Withdrawn

• Conditions: Postoperative Pain Management After Total Hip Arthroplasty
• Interventions: Other: Normal Saline; Drug: Lidocaine

• Registration Number: NCT01108562
• Lead Sponsor: Loma Linda University

Brief Summary

This study will focus on patients undergoing total hip arthroplasty and Loma Linda University Medical Center \& East Campus. These patients will be randomized to receive a low dose lidocaine infusion or placebo, in addition to the patient controlled analgesia pump. These groups will be compared to one another statistically to determine which group shows the safest and most satisfying pain control.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Primary Completion: 2008-08
• Study First Submitted: 2010-04-20
• Study First Submitted QC: 2010-04-20
• Study First Posted: 2010-04-22
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-02
• Last Update Posted: 2015-04-06

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Adult male or female undergoing a total hip arthroplasty Subject is American Society of Anesthesiologists physical status 1, 2, or 3 Subject has voluntarily signed and dated the informed consent document approved by the IRB Be English speaking

Exclusion Criteria

• Age > 80 years old or younger than 18 years old Congestive heart failure Hepatic insufficiency Neurological disorders Psychiatric disorders Steroid treatment No history of atrial fibrillation Chronic pain disorder with opioid treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control Group	Normal Saline	Patients will receive a Dilaudid PCA in combination with a placebo infusion of normal saline.
Lidocaine Group	Lidocaine	Patients will be receive a Dilaudid PCA in combination with a continuous Lidocaine infusion.

Primary Outcome Measures

Name	Time	Method
We propose to test the hypothesis that adding a low dose lidocaine infusion to patient controlled analgesia will lower the amount of opioids that these patients will receive, thereby improving patient safety while still providing adequate analgesia.	24 hours