Establishing Normal Values for Neuropsychological Testing in HIV-negative Thais
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 494
- 试验地点
- 1
- 主要终点
- To establish normal values for neuropsychological testing in HIV negative Thais stratified by age (1 decade) and education
研究概览
简要总结
The purpose of this study is to establish normal values for neuropsychological testing in HIV negative Thais stratified by age (1 decade) and education (no certificate or primary school certificate, less than high school certificate or vocational certificate, high school certificate or higher vocational certificate or diploma, Bachelor degree or higher.
详细描述
The Southeast Asia Research Collaboration with Hawaii (SEARCH) operates or collaborates on several neuroAIDS research protocols. To allow accurate interpretation of neuropsychological data, normative data that are obtained in a similar population are needed. Currently, there are limited such data available for this purpose.
The SEARCH 001 study evaluated the neurocognitive changes before and after highly active antiretroviral therapy in 30 HIV positive subjects and has also enrolled 230/300 proposed HIV-negative controls for this purpose. Normative data tables typically require many more individuals so that age and education strata can be established. We now propose to enroll up to 1000 HIV-seronegative individuals for this purpose.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female
- •Negative HIV antibody at screening
- •Have the ability to understand the study and signed the informed consent form
排除标准
- •Head injury with loss of consciousness greater than 1 hour
- •Current or past illicit drug use or positive drug screen for amphetamine, methamphetamines, cocaine, marijuana, or narcotics
- •Severe illness within 30 days prior to entry
- •Current or recent fevers or meningeal signs.
- •History of pre-existing neurologic disease to include stroke, multiple sclerosis or autoimmune disease.
- •active major depression will be excluded as well - patients with past depression that is controlled and patients with or minor depressive symptoms will be allowed to enroll.
- •Known learning disability including dyslexia
- •Confusion or other signs and symptoms of metabolic encephalopathy or delirium
- •Focal neurological deficit on examination
- •Examining physician's concern that participant may not be able to complete visit requirements.
结局指标
主要结局
To establish normal values for neuropsychological testing in HIV negative Thais stratified by age (1 decade) and education
时间窗: July 31, 2014
次要结局
- To estimate the learning effect on these test at 6 months and 12 months.(July 31, 2014)
研究者
Assoc.Prof.Jintanat Ananworanich, M.D.
Assoc.Prof.
SEARCH Research Foundation