Relation Between Lymphocyte-to-C-Reactive Protein Ratio and Coronary Artery Disease Complexity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 600
- 主要终点
- Relationship between Lymphocyte-to-CRP ratio and CAD complexity assessed by Syntax score
研究概览
简要总结
Aim(s) of the Research :
- To assess the relationship between the lymphocyte-to-CRP ratio and CAD complexity as assessed by Syntax score in both emergency (STEMI patients undergoing PPCI) and elective settings (patients undergoing scheduled CA plus PCI).
- To test the relation between the LCR ratio and short-term major adverse cardiac events (MACE) within 6 months duration in patient undergoing primary PCI.
详细描述
Cardiovascular diseases (CVD) remain the leading cause of mortality globally, responsible for approximately 17.9 million deaths annually, with over 75% occurring in low- and middle-income countries . Coronary artery disease (CAD is the leading contributor to cardiovascular-related deaths. It accounts for 45% of total fatalities linked to cardiovascular conditions .
ST-segment elevation myocardial infarction (STEMI), a severe manifestation of coronary artery disease (CAD), is a medical emergency requiring immediate revascularization to prevent irreversible myocardial damage and reduce mortality .
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for STEMI, significantly reducing mortality and major adverse cardiovascular events (MACE) compared to fibrinolysis . The complexity of coronary lesions during PCI is quantified using the Syntax score, an angiographic tool that predicts procedural success and long-term outcomes . A higher Syntax score indicates increased lesion complexity, worse prognosis, and a greater risk of complications, including arrhythmias, cardiogenic shock, and heart failure .
Vascular inflammation is a key factor in the onset, progression, plaque instability, and eventual rupture of atherosclerosis . As a result, numerous inflammatory biomarkers have gained significant interest.
The inflammatory process begins with the infiltration of inflammatory cells and plays a central role in atherosclerosis, starting from its earliest stages. As atherosclerosis progresses, inflammation has been strongly associated with strokes and acute myocardial infarctions (MI) .
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 80 years
- •Diagnosed with STEMI undergoing primary PCI within 12 hours of symptom onset
- •Patients undergoing elective PCI with documented coronary artery disease
- •Provided written informed consent
排除标准
- •Previous history of myocardial infarction, PCI, or coronary artery bypass grafting (CABG)
- •Diagnosed autoimmune or chronic inflammatory disorders
- •Active infection or malignancy at the time of presentation
- •Severe renal impairment (eGFR <30 mL/min/1.73 m²) or hepatic dysfunction
- •Use of immunosuppressive therapy
- •Diagnosis of acute or chronic leukemia within the past 6 months
结局指标
主要结局
Relationship between Lymphocyte-to-CRP ratio and CAD complexity assessed by Syntax score
时间窗: At baseline during coronary angiography
To assess the correlation between the lymphocyte-to-C-reactive protein (LCR) ratio and coronary artery disease (CAD) complexity as measured by Syntax score in STEMI and elective PCI patients.
次要结局
- Association between Lymphocyte-to-CRP ratio and short-term major adverse cardiac events (MACE)(Within 3 months after PCI)
研究者
Alsayed Ali Mahmoud Ahmed
Principal investigator, Department of cardiology, Assiut University
Assiut University