Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia, a Randomised Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- The change of plasma volume measured by 125I-HSA before anesthesia induction until 50 minutes after anesthesia induction.
研究概览
简要总结
The arterial blood pressure is thought to affect the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the plasma volume. During induction of anesthesia blood pressure, hemoglobin level and hematocrits decreases and the plasma volume increases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the increase in 125 iodine-labeled human serum albumine (125I-HSA) measured plasma volume.
详细描述
24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Equal anesthesia in both groups will be monitored. No fluids will be infused.
Changes in vascular resistance and cardiac output will be measured with thermodilution and changes in plasma volume will be measured with 125I-HSA.
Endothelial cell function will be evaluated by measuring leakage of 125I-HSA and the plasma concentration of endothelial cell markers. Hormonal effects will be evaluated by measuring the plasma concentration of atrial natriuretic peptide (ANP). Shedding of glycocalyx will be evaluated by measuring heparan sulphate. The level of fibrinogen and platelet function will be evaluated by thromboelastography/multiplate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective coronary artery surgery patients
排除标准
- •Age under 40 years
- •Untreated hypertension
- •A reduced left ventricular systolic ejection fraction of 45% or less
- •Diabetes mellitus
- •Former stroke and/or a known carotid artery stenosis
研究组 & 干预措施
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
干预措施: Norepinephrine (Drug)
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
干预措施: Maintained blood pressure (Procedure)
结局指标
主要结局
The change of plasma volume measured by 125I-HSA before anesthesia induction until 50 minutes after anesthesia induction.
时间窗: 50 minutes from anesthesia induction
To assess if the increase in plasma volume measured by 125I-HSA can be reduced by maintaining the blood pressure with vasopressor infusion.
次要结局
- Difference in 125I-HSA leakage(50 minutes from anesthesia induction)
- ANP, heparan sulphate, thrombomodulin, fibrinogen, ROTEM(50 minutes from anesthesia induction)
研究者
Tor Damén
Doctor
Sahlgrenska University Hospital, Sweden