Storage Temperature and Quality of Leucoreduced Whole Blood
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 2
- 主要终点
- Platelet function
研究概览
简要总结
In a combat situation the need for safe and high-quality blood products is increasing. WB (Whole Blood) is used in many trauma situations, but we wish to investigate whether there is an even better whole blood product.
The purpose of this study is to examine the quality of leucoreduced, cold-stored whole blood. We also wish to examine the effects of filtration of whole blood without a 1-2 hour holding-time (warm-filtration) and the effects of forced filtration. We also wish to explore the possibility of using cold-stored WB for production of RCC.
Analyses are performed with a main focus to investigate function and quality of red blood cells and platelets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer
- •Age between 18 and 70
- •Negative pregnancy test (women in fertile age)
- •Blood pressure range: (160-100)/(100-40)
- •Pulse range: 40-100
排除标准
- •Usage of platelet-influencing medication
- •Mild flu or more severe illnesses
- •Open wound
- •Pregnancy or trying to get pregnant
结局指标
主要结局
Platelet function
时间窗: After 10 days of cold-storage
Platelet function is assessed by various parameters, such as thrombelastography (TEG), Multiplate and flow cytometry (Lactadherin, Calcein violet AM, ++).
次要结局
- Leukocyte count(After leukocyte filtration)