Biochemical Alterations of Stored Erythrocyte Membranes

Completed

• Conditions: Coagulation
• Interventions: Other: protein expression pattern of packed red blood cells

• Registration Number: NCT02639780
• Lead Sponsor: Medical University of Vienna

Brief Summary

The investigators will define procoagulant properties of packed red blood cells and investigate whether packed red blood cells from certain donor populations are prone to induce procoagulant states.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12
• Study First Submitted: 2015-12-21
• Study First Submitted QC: 2015-12-23
• Study First Posted: 2015-12-24
• Primary Completion: 2019-11
• Study Completion: 2021-12
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-01
• Last Update Posted: 2022-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• group 1: healthy female volunteers 18-35 y.o.
• group 2: healthy male volunteers 18-35 y.o.
• group 3: healthy female volunteers 36-60 y.o.
• group 4: healthy male volunteers 36-60 y.o.
• group 5: female volunteers 36-60 y.o., BMI 26-45
• group 6: male volunteers 36-60 y.o., BMI 26-45

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Exclusion Criteria

• age below 18 years
• age above 60 years

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
obese older female	protein expression pattern of packed red blood cells	-
healthy young male	protein expression pattern of packed red blood cells	-
healthy older male	protein expression pattern of packed red blood cells	-
obese older male	protein expression pattern of packed red blood cells	-
healthy young female	protein expression pattern of packed red blood cells	-
healthy older female	protein expression pattern of packed red blood cells	-

Primary Outcome Measures

Name	Time	Method
protein expression pattern	week 6

Trial Locations

Locations (1)

Medical University of Vienna; 🇦🇹 Vienna, Austria