Insulin Sensitivity and Transforming Growth Factor- beta (TGF-ß) Signalling in Women with Polycystic Ovary Syndrome

Victoria University0 个研究点目标入组 45 人开始时间: 2018年2月1日最近更新: 2019年7月15日

适应症

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•Premenopausal women aged between 18-45 with PCOS.
•PCOS will be diagnosed by Rotterdam Criteria which requires two ofthe following;
•1. Oligoovulation (irregular ovulation) or anovulation (lack of ovulation),
•2. Clinical and/or signs of hyperandrogenism,
•3. Polycystic ovaries and exclusion of other causes of hyperandrogenism.
•Premenopausal women aged between 18-45 without PCOS, Control women will be defined by having no Rotterdam features.
•Not using hormonal contraceptive methods (pill, implantation)
•Not taking insulin sensitisers or medications which may affect endpoint data.
•Not taking vitamins or natural supplements or have undergone a washout period of 1 month prior to this study.

•Exclusion Criteria. menopause, Secondary causes of menstrual disturbance and hyperandrogenism, pregnancy, smoking, Type 1 diabetes, Type 2 diabetes mellitus, uncontrolled hypertension (>160/100mm/Hg), cardiac ischemia, established cardiovascular disease, renal impairment and malignancy, and use of medications that interfere with endpoints (e.g. contraception, metformin, anti-androgens, and progestins anti-hypertensives, and lipid-lowering agents).

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