JPRN-jRCT1051210194已完成3 期
Verification of improvement in arterial oxygen partial pressure during unilateral lung ventilation of remimazolam for desflurane used for anesthesia management during thoracoscopic lung resection: randomized controlled trial
Yamamoto Kasumi0 个研究点目标入组 31 人开始时间: 2022年3月17日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 31
研究概览
简要总结
Inhaled anesthetics suppress hypoxic pulmonary vasoconstriction (HPV), whereas intravenous anesthetics such as propofol do not suppress HPV and can maintain high PaO2 during OLV. On the other hand, the effect of remimazolam on HPV is unclear. In this study, we compared the effect of remimazolam anesthesia with desflurane anesthesia on PaO2 during OLV in thoracoscopic pneumonectomy. Results showed that PaO2 during OLV was higher with maintenance of anesthesia with remimazolam than with desflurane.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 < 75age old（—）
- 性别
- All
入选标准
- •1.Patients scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation
- •2.American Society Association physical status class 1~3
- •3.Patients who have sufficient judgment to understand the research content and have provided written consent
排除标准
- •Patients who meet any of the following conditions are excluded:
- •1.Scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation for less than 2 hours
- •2.Undergoing bilateral lung surgery
- •3.History of surgery on the ventilated lung
- •4.History of hypersensitivity to the following
- •ingredients of remimazolam
- •desflurane or other halogenated anesthetics
- •remifentanil components or fentanyl compounds
- •rocuronium component or bromide
- •5.History of drug dependence
- •6.History of malignant hyperthermia or a history of malignant hyperthermia in their relatives
- •7.Acute angle-closure glaucoma
- •8.Myasthenia gravis or Congenital myasthenia
- •9.Muscular dystrophy
- •10.Severe aortic regurgitation
- •12.Acute intoxication
- •13.Received nalmefene hydrochloride within the previous week
- •14.Continuously receiving antihypotensive agents
- •15.With a chest tube inserted
- •16. Interstitial pneumonia
- •17.Pregnant or breastfeeding
- •18.Arterial oxygen saturation (SpO2) of less than 95% in room air, or requiring oxygen administration
- •19.Severe liver dysfunction (serum bilirubin level >2.5 mg / dL or PT activity level <50%)
- •20.BMI of less than 15 kg/m2 or more than 30 kg/m2
- •21.QTc is greater than or equal to 450 msec (according to Bazett's correction formula) on preoperative electrocardiogram
- •22.Arrhythmia more than 3 times per minute on electrocardiogram
研究者
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