NCT00725179已完成不适用
Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Duration of oral vs IV NAC treatment in hours
研究概览
简要总结
Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to CHMCA between June 1, 2004 to May 31, 2008 with a qualifying ICD-9 diagnosis code for the following APAP overdose situations; poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0)
- •Serum APAP concentrations ≥ 150 g/mL at 4 hours or a serum concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained > 4 hours post ingestion
- •Between the ages of 0-21 years
排除标准
- •Serum APAP concentrations are not actually documented
- •Patient did not receive oral or IV NAC treatment
- •Patient has a preexisting liver disease such as cirrhosis or hepatitis C
- •Patient > 21 years of age
结局指标
主要结局
Duration of oral vs IV NAC treatment in hours
时间窗: From admission to discharge
次要结局
- Overall healthcare costs associated with IV vs Oral NAC treatment(From admission to discharge)
研究者
Martha Blackford
PharmD
Akron Children's Hospital
研究点 (1)
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