A Randomized Crossover Study of Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Sputum induction by physiotherapists maneuvers
研究概览
简要总结
This study evaluated whether physiotherapy is efficient in sputum induction and in evaluation of pulmonary inflammation in asthmatic children.
详细描述
The hypertonic saline is a traditional technique to collect induced sputum, it´s safe and viable in asthmatic children, as well as the technique of sputum induction and processing has been standardized for schoolchildren.
Sometimes researchers have difficulties to obtain induced sputum in stable patients and it´s possible to use physiotherapy maneuvers to induced sputum. The manouvers are safe for adult and children asthmatics stable.
This study aimed to evaluate the effectiveness to collect induced sputum by physiotherapy maneuvers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Asthmathic children used inhaled corticosteroids not associated with long-acting beta2-agonist.
排除标准
- •Asthmathic children to diagnose with other chronic pulmonary pathologies (cystic fibrosis, ciliary dyskinesia, bronchiolitis obliterans, and bronchopulmonary dysplasia) before study, no significant pulmonary pathologies, incapacity to realize pulmonary function and insufficient sample.
研究组 & 干预措施
physiotherapists maneuvers
physiotherapy techniques
干预措施: physiotherapy techniques (Other)
hypertonic saline 3%
four nebulizations with 3% hypertonic saline.
干预措施: hypertonic saline 3% (Other)
saline + physiotherapy maneuvers
1 nebulizations + physiotherapy techniques
干预措施: saline + physiotherapy maneuvers (Other)
结局指标
主要结局
Sputum induction by physiotherapists maneuvers
时间窗: 3 days
children were seated in a position where the thorax was inclined forwards by 45°, they were instructed to perform calm and long exhalations by oscillating positive expiratory pressure (OPEP) during nonstop 5 minutes holding a Flutter® (Scandipharm, Birmingham, AL, EUA). After that, children were positioned in supine zero degree and underwent for more five minutes to a forced exhalation with the open mouth/glottis (huffing) associated to acceleration by forced expiratory technique (FET), performed by the therapist by positioning a hand on xiphoid process and the other in the manubrium sternum.
次要结局
- Sputum induction by hypertonic saline 3%(3 days)
研究者
Beatriz Mangueira Saraiva Romanholo
PhD
University of Sao Paulo