跳至主要内容
临床试验/NCT06700005
NCT06700005招募中不适用

ReadMap: Reading in Stroke Alexia and Typical Aging

Georgetown University1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2023年1月12日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
300
试验地点
1
主要终点
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

研究概览

简要总结

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

时间窗: Collected within 1 month of behavioral testing

Part of MRI sequence that measures deep grey matter structure.

DTI (Diffusion Tensor Imaging)

时间窗: Collected within 1 month of behavioral testing

Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

Behavioral testing

时间窗: Collected within 1 month of MRI

Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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