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临床试验/NCT07407621
NCT07407621Enrolling By Invitation不适用

Effects of Short Isokinetic Eccentric Resistance Training on Neuromuscular Induced Adaptations Among Obese, Untrained Women

Universiti Sains Malaysia1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2025年1月2日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
Enrolling By Invitation
入组人数
24
试验地点
1
主要终点
Maximal voluntary strength

研究概览

简要总结

The study compares the impact of isokinetic resistance training (RT) -induced neuromuscular adaptation following an 8-week short ECC ISO RT and CON ISO RT among obese, untrained women. The main question it aims to answer is:

1. Does exercise-induced neuromuscular adaptation following progressive short ECC ISO RT, more effectively than CON ISO RT, among obese, untrained women?

Researchers will compare drug ECCISO RT to a CONISO RT to see if ECCISO RT is more effective in inducing neuro-muscular adaptations in obese, untrained women.

Participants will:

  1. Train on isokinetic ECC or CON for 8 weeks
  2. Visit the clinic twice for baseline and post tests

详细描述

1.1 Introduction

Exercise-induced neuromuscular and functional changes are mode-specific. Exercise-induced muscular adaptations may be influenced by mechanical tension, subcellular damage, and metabolic stress. Eccentric (ECC) contraction happens when the external force exerted on the muscle exceeds the momentary force generated by the muscle. As a result, the muscle's strength is sufficient to overcome the load or resistance that causes the muscle to lengthen. Compared with concentric (CON) or isometric (ISO) contractions, ECC training elicits greater mechanical strain and microlesions in the muscles, which may lead to more pronounced muscular adaptations. ECC exercise is traditionally performed against a constant external load or at a constant velocity (isokinetic). Depending on the type of training, this produces varying mechanical demands, resulting in distinct neuromuscular and muscle-tendon adaptation mechanisms. In contrast to ISO or CON muscular contractions, the central nervous system employs a distinct neural strategy to govern skeletal muscle contraction. Different activation levels among synergistic muscles during ECC contractions compared with CON contractions, and the preferential recruitment of rapid-twitch motor units, are two examples of how this is demonstrated.

1.2 Problem statement & study rationale

Emerging data suggest that adiposity is associated with muscular weakness and reduced muscle quality. Regular resistance training (RT) has been shown to enhance a muscle's maximal regenerative capacity. It is believed that neural mechanisms primarily contribute to the initial (<2-4 weeks) gains in muscle force production during resistance training, followed by adaptations in muscle morphology (>5-8 weeks). However, this evidence is based on combining both ECC and CON contraction exercises. Studies have shown that ECC contraction elicits greater neuromuscular adaptation than CON contraction. Therefore, ECC RT is a promising approach for individuals with muscular weakness, such as the obese. Hence, it is postulated that short progressive eccentric isokinetic resistance training (ECCISO RT) will increase neuromuscular adaptations in obese untrained women compared to concentric isokinetic resistance training (CONISO RT)

2.0 Literature Review

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Eumenorrheic women (reporting menstrual cycle between 21-35 days)
  • Age 25-45 y/o
  • BMI > 23.0 kg/m2
  • Body fat percentage > 30%
  • No lower limb orthopaedic injuries
  • Have not participated in any structured/ unstructured weight loss intervention in the past 12 months
  • Sedentary lifestyle (regular exercise <1 hour per week)
  • Stable body weight (loss or gain of no greater than 2 kg)
  • Stable medication use for six months before enrolment

排除标准

  • taking supplements or medication known to affect REE (such as oral contraceptives)
  • severe medical conditions affecting their physical or mental health
  • individuals with an implanted medical device
  • suffer from alcohol or drug abuse
  • trying to conceive/ pregnant, or breastfeeding

研究组 & 干预措施

ECC ISO

Experimental

Eccentric Isokinetic Exercise

干预措施: ECC ISO (Other)

CON ISO

Active Comparator

Concentric Isokinetic Exercise

干预措施: CON ISO (Other)

结局指标

主要结局

Maximal voluntary strength

时间窗: 8 weeks

Changes in maximal voluntary strength

Neural activation assessment

时间窗: 8 weeks

Changes in neural activation during strength

Fasting plasma glucose

时间窗: 8 weeks

Changes in fasting plasma glucose

Functional physical fitness (6-minute walking test)

时间窗: 8 weeks

Changes in distance during 6-minute walking test

Indirect calorimetry

时间窗: 8 weeks

Changes in basal metobolic rate/ fat oxidation rate/ charbohydrate oxidation rate

HDL cholesterol

时间窗: 8-weeks

Changes in HDL cholesterol

LDL cholesterol

时间窗: 8-weeks

Changes in LDL cholesterol

Total cholesterol

时间窗: 8-weeks

Changes in total cholesterol

Trigliceride

时间窗: 8-weeks

Changes in triglyceride

次要结局

  • Percentage of Body Fat(8 weeks)
  • Lean muscle mass(8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nazirah Gulam Mohamed

Mrs

Universiti Sains Malaysia

研究点 (1)

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