In Vivo Molecular Imaging of Epidermal Growth Factor Receptor in Patients With Colorectal Neoplasia Using Confocal Laser Endomicroscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
The study aims to:
- Achieve molecular imaging of EGFR in patients with colorectal neoplasia in vivo using confocal laser endomicroscopy.
- Compare the results of in vivo EGFR-specific molecular imaging with CLE and ex vivo immunohistochemistry .
详细描述
Various kinds of tumor markers have been shown to be over-expressed in colorectal cancer, including epidermal growth factor receptor(EGFR). The conventional detection method of EGFR expression in colorectal neoplasia is immunohistochemistry which is time-consuming, and the immunoreactivity can be affected by storage and fixation of tissues. Confocal laser endomicrosopy is a newly developed device which could identify the cellular and subcellular structures clearly with the magnification at×1000, making it possible to explore the physiological and pathological molecular mechanism of the gastrointestinal tract. So the study aims to achieve molecular imaging of EGFR in colorectal neoplasia in vivo using confocal laser endomicroscopy.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Patients who are allergic to fluorescein sodium
- •Patients with impaired cardiac, liver or renal function
- •Patients who are unwilling to sign or give the informed consent form
- •Patients with giant tumors or obvious GI tract bleeding which make it hard or impossible to observe the lesions
- •Patients with coagulopathy
- •Patients with pregnancy or breastfeeding
研究者
Yanqing Li
Chief of the Department of Gastroenterology, Qilu Hospital, Shandong University
Shandong University