Comparison of Transcutaneous Carbon Dioxide Monitoring With Arterialized or Arterial Blood Gas Analysis in PICU
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Partial CO2 difference
研究概览
简要总结
Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling. However, the accuracy of tPCO₂ may be influenced by factors such as peripheral perfusion, skin temperature, and vasopressor therapy. This prospective observational study compares transcutaneous carbon dioxide measurements with arterialized or arterial blood gas PaCO₂ values in children with respiratory insufficiency, including a subgroup receiving vasopressor support.
详细描述
This prospective observational study will be conducted in a pediatric intensive care unit to assess agreement between transcutaneous carbon dioxide monitoring and arterialized or arterial blood gas analysis. Consecutive pediatric patients aged 1-18 years with respiratory insufficiency or impaired peripheral perfusion requiring vasopressor support will be included if repeated blood gas sampling is clinically indicated.
Paired measurements of tPCO₂ and PaCO₂ will be analyzed using Bland-Altman methods with correction for repeated measures. Subgroup analyses will evaluate the influence of vasopressor therapy on measurement accuracy. Secondary analyses will compare tPO₂ and PaO₂ values. The study aims to define the clinical applicability and limitations of transcutaneous capnometry in critically ill pediatric patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 1-18 years
- •Diagnosis of respiratory insufficiency or impaired peripheral perfusion
- •Expected need for more than one arterialized capillary or arterial blood gas sample
- •Admission to PICU
排除标准
- •Repeated failure of sensor adhesion
- •Hypothermia < 35 °C
- •Time difference > ±5 minutes between tPCO₂ and blood sampling
- •Large tPCO₂ variability (> ±1 kPa) in 15 minutes preceding blood sampling
- •Non-physiological tPCO₂ values incompatible with life
结局指标
主要结局
Partial CO2 difference
时间窗: periprocedural
Agreement between transcutaneous CO₂ (tPCO₂) and arterialized or arterial PaCO₂ assessed using Bland-Altman analysis (bias, SD, 95% limits of agreement).
次要结局
- Vassopressor use(periprocedural)
- Proportion of pCO2(periprocedural)
- Partial O2(periprocedural)
研究者
Petr Štourač, MD
prof. Petr Štourač, MD, PhD, MBA, LLM, FESAIC
Brno University Hospital