Effect of Aerobic Exercises on Sex Hormones and Coagulation Factors in Postmenopausal Elderly Women
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- coagulation factors
研究概览
简要总结
PURPOSE:
to determine the effect of aerobic exercise training on sex hormones and coagulation factors in postmenopausal elderly women
BACKGROUND:
Cardiovascular disease (CVD) is the largest cause of death in women, and the risk of developing CVD increases after menopause . Because thrombosis is thought to be a cause of most acute cardiovascular events, abnormalities in endogenous coagulation and fibrinolysis may play an important role in the risk of an acute cardiovascular event. Aging is also associated with adverse changes in both coagulation and fibrinolysis. For instance, postmenopausal women exhibit higher fibrinogen levels and lower levels of endogenous fibrinolysis. Physical activity and physical fitness have consistently been linked to lower CVD rates in women. In fact, an inverse association between physical activity and total mortality, as well as a 50% reduction in risk of myocardial infarction, has been observed in physically active postmenopausal women. In addition to the numerous other benefits provided by regular physical activity, one of the mechanisms mediating the cardioprotective effect may be changes in the hemostatic system, particularly fibrinolysis
HYPOTHESES:
Aerobic exercises may have no effect on sex hormones and coagulation factors in elderly postmenopausal women
RESEARCH QUESTION:
Do aerobic exercises effect on sex hormones and coagulation factors in elderly postmenopausal women in response to exercises?
详细描述
It is an interventional study in which 40 women estimated to enroll according to random allocation and assigned into two groups equally. The study group will receive aerobic exercises in addition to diet recommendations while the control group will receive diet recommendations. the aerobic exercises time of session 40-50 min initial 10 min warm up exercises on treadmill in low intensity and active phase 20- 30 min intensity will increase until patient reach to target heart rate then intensity decrease until session will be ended by cooling down phase for 10 min . The volunteers will perform exercises 3 times per week for 12 weeks .coagulation factors(Prothrombin time, Partial Thromboplastin Time , plasminogen activator inhibitor-1 , fibrinogen and tissue plasminogen activator )will be measured and sex hormones (estradiol ,testosterone. sex hormone binding globin ) pre and post intervention
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •• forty Postmenopausal women (60-70 y)
- •Body mass index (BMI) ranged from 35 to 39.9 kg/m2
排除标准
- •• regular medications(e.g., β-blockers, α-blockers, digoxin, diuretics, aspirin, nitrates, Presently using hormone replacement therapy (HRT) and non steroidal anti-inflammatory drugs,
- •cognitive impairment that will make it difficult to partake in the study
- •presence of malignant disease
- •blood donation within the last 6 months
- •Participation as a subject in any type of study or research during the prior 90 days
- •hypertension,
- •having active chronic illness (e.g., rheumatoid arthritis, hyperthyroidism, and inflammatory bowel disease) and diabetes mellitus or other (unstable) endocrine-related diseases
- •personal history of cardiovascular diseases,
- •Orthopedic problems inhibiting exercises.
结局指标
主要结局
coagulation factors
时间窗: 12 weeks
change of selected coagulation factors by blood analysis (plasminogen activator inhibitor-1 ,tissue plasminogen activator ,Prothrombin time ,Partial Thromboplastin time ,fibrinogen )
sex hormones
时间窗: 12 weeks
change of (estradiol ,testosterone. sex hormone binding globin )
次要结局
- weight(12 weeks)
- height(12 weeks)
研究者
Hany Farid Eid morsy Elsisi
principal investigator
Cairo University