Supra and subglottic instillation of dexmedetomidine for prevention of coughing during emergence from general anaesthesia : A comparison with lignocaine .
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- To assess the incidence and severity of coughing during emergence from general anesthesia
研究概览
简要总结
So far no study has detected the local action of dexmedetomidine on tracheal mucosa in patients undergoing endotracheal intubation. Therefore we hypothesize that direct instillation of dexmedetomidine via supra/subglottic injectable endotracheal tube port could suppress cough reflex following tracheal extubation.
This prospective, randomized, double blinded trial will compare the safety and efficacy of direct instillation of tracheal mucosa by dexmedetomidine and lidocaine via a supra or subglottic injectable endotracheal port forsmooth tracheal extubation in patients undergoing general surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Consent for participation
- •Scheduled for elective surgery under genaral anaesthsia.
排除标准
- •Refusal of Patient.
- •With Known contraindication and sensitivity of study drugs
- •History of asthma or COPD
- •Who requires post op ventilation
- •Anticipated difficult airway
- •history of tracheal surgery.
结局指标
主要结局
To assess the incidence and severity of coughing during emergence from general anesthesia
时间窗: Time POINT - JUST AFTER EXTUBATION, 1min post extubation, 2 min post extubation, 3 min post extubation, 4 min post extubation, 5 min post extubation
次要结局
- 1. Extubation Time(2. Hemodynamic Parameters)
研究者
DR HARSHA
INDIRA GANDHI INSTITUTE OF MEDICAL SCIENCES