Can Increased Dietary Protein Prevent the Suppression of Metabolism and Maintain Anabolic Sensitivity of Bone and Skeletal Muscle During Caloric Restriction?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in Circulating IGF-1
研究概览
简要总结
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
详细描述
- Preliminary testing
Prior to the study start, participants will be weighed and body composition will be determined using calipermetry (7 sites) and bioelectrical impedance. Peak oxygen uptake (VO2peak) will be assessed using an incremental exercise test on a bicycle ergometer. 2. Randomization
Participants will proceed through each of the following conditions lasting 5 days:
CR-LP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be low (0.8 g/kg BW/day).
CR-HP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be high (1.7 g/kg BW/day).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •4 hours/week of purposeful aerobic exercise over the last 3 months
- •Body mass index: 19-25 kg/m2
- •< 15% body fat
排除标准
- •Cardiovascular disease risk factors that would result in greater than low risk
- •Type I, type II diabetes, or history of high fasting glucose;
- •History of high blood pressure and/or use of medication for hypertension;
- •History of Dyslipidemia, or on lipid-lowering medication;
- •Underlying health condition and/or use of medication that could interfere with any of our study outcomes.
- •History or current diagnosis of a clinical eating disorder
- •Failure to adhere to study protocol
结局指标
主要结局
Change in Circulating IGF-1
时间窗: Baseline and day 6
Change in Resting Metabolic Rate
时间窗: Baseline and day 6
Change in Marker of Bone Formation (P1NP)
时间窗: Baseline and day 6
Change in Marker of Bone Resorption (CTx)
时间窗: Baseline and day 6
次要结局
- Change in Body Weight(Baseline and day 6)
- Change in Perceived Hunger(Baseline and day 6)
- Change in Body Fat Percentage(Baseline and day 6)
- Change in Aerobic Fitness (VO2peak)(Baseline and day 6)