Effect of Anesthetic Agents (Propofol, Sevoflurane) on Optic Nerve Sheath Diameter(ONSD) in Patients Undergoing Robot-assisted Laparoscopic Gynecology Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- difference of optic nerve sheath diameter
研究概览
简要总结
The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.
详细描述
Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases.
Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy
排除标准
- •history of brain hemorrhage or brain infarction
- •liver disease or end stage renal disease
- •glaucoma or any signs of increased intraocular pressure
- •combined wtih other types of operation
- •patient refusal
- •weight less than 40 kg or over 100 kg
研究组 & 干预措施
Sevoflurane
1.5-2.5 vol% of sevoflurane is used for maintenance of anesthesia.
干预措施: Sevoflurane (Drug)
Propofol
2-5 mcg/ml of propofol is used continuously for maintenance of anesthesia using target-controlled infusion system.
干预措施: Propofol (Drug)
结局指标
主要结局
difference of optic nerve sheath diameter
时间窗: During the operation.
optic nerve sheath diameter is measured using sonographic probe. (10 minutes after induction of anesthesia/ 5 minutes after pneumoperitoneum and trendelenburg position / 20 minutes after pneumoperitoneum and trendelenburg position / 40 minutes after pneumoperitoneum and trendelenburg position / skin closure)
次要结局
未报告次要终点