Evaluation of Bone Remodeling Markers Following Non-surgical Periodontal Therapy in Periodontitis Patients (Prospective Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Bone remodeling markers including salivary RANKL
研究概览
简要总结
Previous studied have investigated the pathophysiological role and expression of Cathepsin K (Ctsk) , receptor activator of the NF-κB ligand (RANKL) and periostin in active periodontitis and peri-implantitis lesions. However, the potential influence of non-surgical periodontal therapy including scaling and root planning on the bone remodeling markers level over different trial times have not well determined. Thus, the current research is conducted to address this influence. Thus, the research question will be: In patients with periodontitis, does the level of bone remodeling markers altered after successful NSPT during different healing time periods?
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Both males and females.
- •Unstable periodontitis.
- •No previous periodontal treatment is conducted during the past 6 months.
- •Good general health without history of any systemic diseases.
- •Present with at least 20 teeth.
- •Non-smokers.
排除标准
- •Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances.
- •Subjects receiving antibiotic therapy during the previous 3 months.
- •Pregnant or lactating women.
- •Not willing to participate or continue to conduct the study.
结局指标
主要结局
Bone remodeling markers including salivary RANKL
时间窗: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
To investigate the alterations in the level of salivary RANKL pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Bone remodeling markers including salivary Cathepsin k
时间窗: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
To investigate the alterations in the level of salivary Cathepsin k pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
Bone remodeling markers including salivary periostin
时间窗: At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit
To investigate the alterations in the level of salivary periostin pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods.
次要结局
- Clinical periodontal parameters including probing pocket depth(At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit)
- Clinical periodontal parameters including clinical attachment loss(At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit)
- Clinical periodontal parameters including Bleeding on probing(At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit)
研究者
Firas Bashir Hashim Al-Taweel
Assistant Professor
University of Baghdad