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临床试验/NCT00262587
NCT00262587已完成4 期

Elite Sport and Development of Asthma

Bispebjerg Hospital1 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2005年9月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
4 期
状态
已完成
入组人数
18
试验地点
1
主要终点
Eucapnic voluntary hyperventilation (EVH)

研究概览

简要总结

International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects. It is unclear whether the increased prevalence of asthma in elite athletes reflects "traditional asthma" or whether it is a special form of "sports asthma". The treatment of elite athletes with asthma seems to vary widely, and only a few studies have focused on the treatment of elite athletes with asthma. Further knowledge of the pathogenesis of sports asthma would lead to a greater understanding and better treatment of the condition. This study will investigate the type of airway inflammation in elite athletes and examine the effect of treatment with inhaled steroids in combination with long-acting beta-agonists versus placebo in the same group.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Elite athletes
  • Informed consent
  • Doctor diagnosed asthma

排除标准

  • Current smoker or more than 10 pack-years
  • Pregnancy, breast feeding or planning pregnancy during the study.
  • ICS within the last 4 weeks prior to visit 1.

研究组 & 干预措施

Placebo

Placebo Comparator

Placebo inhaler (sugar powder)

干预措施: Placebo (Drug)

Seretide

Active Comparator

Seretide inhaler

干预措施: Seretide (Drug)

结局指标

主要结局

Eucapnic voluntary hyperventilation (EVH)

时间窗: End of study

Exhaled Nitric Oxide

时间窗: End of study

次要结局

  • Respiratory symptoms(End of study)
  • Lung function(End of study)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Thomas Lund

MD

Bispebjerg Hospital

研究点 (1)

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Elite Sport and Development of Asthma | 临床试验