Host-Microbiota Interactions Across the Gut Immune System: Characterization of Phenotype and Genotype of Early Onset Enteropathies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,445
- 试验地点
- 12
- 主要终点
- Increasing the current rate (20%) of genetic characterization of early onset entheropathies
研究概览
简要总结
This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies.
In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early onset enteropathies and their healthy relatives.
详细描述
This study specifically aims at the genetic analysis of early onset enteropathies with the goal in mind to delineate human pathways necessary to maintain intestinal homeostasis despite the considerable density of microbes colonizing the distal part of the human intestine.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Severe chronic enteropathy
- •Patients developing their first symptoms within the first 6 years of life and, in priority within the first two years of life, or patients with a disease of later onset, in case of a familial history suggestive of inherited mutations notably in families comprising several affected members
- •OR : Be a patient's relative, even if presenting with enteropathy of later onset.
排除标准
- •Subject having participated to any therapeutical clinical study in the 30 days preceding the inclusion in this study,
结局指标
主要结局
Increasing the current rate (20%) of genetic characterization of early onset entheropathies
时间窗: 40 years
Currently, around 20% of early onset entheropathies are genetically characterized. Investigators want to increase this rate via this research protocol. Our long term objective is to characterize phenotypes and genotypes of patients with early onset enteropathies.
次要结局
未报告次要终点