Follicular Flushing in Patients With Mono-follicular Growth
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 71
- 试验地点
- 1
- 主要终点
- mature oocyte
研究概览
简要总结
Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle. Flushing the follicle with multiple aspirations from the same follicle is used as a means to increase the ratio of COC per aspirated follicle. Data showed that follicular flushing is not superior to direct aspiration either in normally responding patients or in poor responders undergoing in vitro fertilization (IVF). There is no data in the literature regarding the issue in patients with mono-follicular growth. Direct aspiration or repeatedly flushing the follicle for those with a single follicle will be investigated.
详细描述
Oocyte retrieval procedure This study aims to evaluate the effect of follicular flushing during oocyte retrieval procedure in patients with only one follicle. Double lumen needle will be used and direct follicular aspiration without flushing will be performed for all patients. If an oocyte will be obtained, the patient will be assigned to group A. If not, at least 1 course of follicular flushing will be used until retrieval of an oocyte and the patient will be assigned to group B.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women aged 18-40 years
- •primary infertility
- •diminished ovarian reserve with single mature follicle on the day of oocyte retrieval
排除标准
- •natural cycle IVF
- •presence of endometriosis/endometrioma(s)
- •Absence of cumulus oocyte complex following oocyte retrieval
- •Severe male factor infertility
- •Pre-implantation genetic screening cycles
结局指标
主要结局
mature oocyte
时间窗: during oocyte retrieval procedure
Confirmation of cumulus oocyte complex (COC) after microscopic examination of follicular fluid by a senior embryologist for each patient.
次要结局
- fertilization rate after micro-injection(24 hours after microinjection procedure)
- clinical pregnancy rate per embryo transfer(untill 6 weeks)
研究者
Emre Göksan Pabuçcu
Emre G. Pabuccu, Assoc. Prof.
Centrum Clinic IVF Center