Predictors of Prolonged Mechanical Ventilation in Preterm Infants Admitted to Neonatal Intensive Care Unit of Assiut University Children Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Occurrence of prolonged mechanical ventilation
研究概览
简要总结
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
详细描述
Prolonged mechanical ventilation in preterm infants is associated with increased morbidity including bronchopulmonary dysplasia and neurodevelopmental impairment. This prospective observational study will include preterm infants (born before 37 completed weeks) who require invasive mechanical ventilation.
Infants will be classified into two groups according to the duration of invasive mechanical ventilation: prolonged (>7 days or frequent reintubation) and non-prolonged (≤7 days). clinical, perinatal, and laboratory predictors of prolonged mechanical ventilation will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 36 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Preterm infants born before 37 completed weeks of gestation
- •Admission to the NICU within the neonatal period
- •Requirement for invasive mechanical ventilation
- •Written informed consent from parents or legal guardians
排除标准
- •- Infants born after 37 weeks of gestation
- •Major congenital anomalies
- •Chromosomal abnormalities
- •Congenital neuromuscular disorders
- •Cyanotic congenital heart disease
研究组 & 干预措施
Prolonged Mechanical Ventilation
Preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation
Non-Prolonged Mechanical Ventilation
Preterm infants who require invasive mechanical ventilation for ≤7 days.
结局指标
主要结局
Occurrence of prolonged mechanical ventilation
时间窗: Up to 30 days
Proportion of preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation.
次要结局
- In-hospital mortality(Up to 30 days)
- Duration of invasive mechanical ventilation(Up to 30 days)
- Successful extubation rate(Up to 30 days)
- Incidence of bronchopulmonary dysplasia(Up to 30 days)
- Incidence of neonatal sepsis(Up to 30 days)
- Duration of NICU stay(Up to 30 days)
研究者
Demiana Youssef Zakaria Ghaly
Resident Physician
Assiut University