Machine Learning to Identify Metabolic Subtypes of Non-Alcoholic Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- histological cirrhosis checklist
研究概览
简要总结
The purpose of this study was to use machine learning to explore a more precise classification of NAFLD subgroups towards informing individualized therapy.
详细描述
Clinical characteristics of NAFLD are heterogenous, but current classification for diagnosis is simply based on pathological examination. The conventional pathological classification is insufficient to reflect the complexity and heterogeneity of NAFLD and can not predict the prognosis. Towards precision treatment, a more refined metabolic classification of NAFLD phenotypes is highly demanded for a personalized diagnosis, aiming to identify patients at elevated risk of cardiovascular disease or cirrhosis. This kind of refined classification can provide a more precise diagnosis and enable more individualized preventive interventions and early treatments. In a cross-sectional cohort, unsupervised machine learning was used to cluster patients with biopsy-proved NAFLD from Drum Tower Hospital Affiliated to Nanjing University Medical School based on clinical variables. Verification of the clustering was performed in a longitudinal cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •biopsy-proved NALD cohort:
- •age 18 to 75 years
- •receiving liver biopsy at the time of metabolic surgery
- •relatively complete clinical information, including physical examination, biochemical and haematological assessments
- •longitudinal cohort
- •age 18 to 75 years
- •receiving abdominal imaging examinations,
- •relatively complete clinical information, including physical examination, biochemical and haematological assessments (4）follow-up time at least more than 12 months
排除标准
- •(1)consumed excessive alcohol (≥140 g/week for males or ≥ 70 g/week for females) •
- •(2) with history of other liver diseases including chronic hepatitis, biliary obstructive diseases or autoimmune hepatitis
结局指标
主要结局
histological cirrhosis checklist
时间窗: up to 5 years
cirrhosis was defined as widespread disruption of normal liver structure by the formation of pseudolobules or Scheuer stage 4 fibrosis in pathological findings.
Ischemic heart disease
时间窗: up to 5 years
Objective Findings of Coronary Stenosis (≥ 50%) in at least 2 coronary artery territories (ie, left anterior descending, ramus intermedius, left circumflex, right coronary artery) involving the vain vessel, a major branch, or a bypass graft
Documented heart disease checklist
时间窗: up to 5 years
Documented Myocardial Infarction or Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting
hepatocellular carcinoma
时间窗: up to 5 years
the diagnosis of hepatocellular carcinoma was based on well-established diagnostic imaging criteria and/or histology.
次要结局
未报告次要终点
研究者
Yan Bi
Chief Physician
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School