Développement Cognitif et cérébral Chez Les Adolescents Souffrants d'un Syndrome de Gilles de la Tourette
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Behavioral test main outcome measures [4]
研究概览
简要总结
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.
详细描述
Thus, the aims of the present project is threefold:
Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents.
To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency.
Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches.
Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Tourette syndrome
- •Ages 13 - 18
- •Acceptance to perform the Brain MRI
- •Acceptance to perform the cognitive testing
- •Acceptance to perform the TMS measures
排除标准
- •Learning disability
- •Incompatibility with MRI procedure (metal body implants, pregnancy)
研究组 & 干预措施
Tourette syndrome
Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures
干预措施: brain MRI (Other)
Tourette syndrome
Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures
干预措施: Behavioral testing on cognitive computerized tasks (Behavioral)
Tourette syndrome
Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures
干预措施: TMS (Other)
Controls
Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures
干预措施: Behavioral testing on cognitive computerized tasks (Behavioral)
Controls
Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures
干预措施: brain MRI (Other)
Controls
Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures
干预措施: TMS (Other)
结局指标
主要结局
Behavioral test main outcome measures [4]
时间窗: from 16 to 20 months
agency composite scores
Behavioral test main outcome measures [2]
时间窗: from 16 to 20 months
discounting factor
Behavioral test main outcome measures [3]
时间窗: from 16 to 20 months
number of premature responses
Brain MRI scan measures
时间窗: from 16 to 20 months
whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology
Behavioral test main outcome measures [1]
时间窗: from 16 to 20 months
reaction times
Transcranial magnetic stimulation
时间窗: from 16 to 20 months
Short Intracortical Inhibition (SICI) scores
次要结局
未报告次要终点