Effect of Whole Flaxseeds and Flaxseed Mucilage on Lipid Absorption, Glucose and Insulin Metabolism and Appetite Regulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- TAG in chylomicrons
研究概览
简要总结
Randomized trial to test the effect of flaxseed fractions on appetite regulation and intestinal lipid absorption.
详细描述
Randomized multiple crossover trial in 18 healthy males aged 18 to 40 years each are required to complete a total of five iso-caloric meal tests lasting approximately 8½ hours. Test meals will be given as breakfast meals, in which different fractions of flaxseeds are incorporated into baked products. Appetite will be registered using visual analogue scales during 7 hours after the test meal and a total of 10 blood samples will be drawn to evaluate TAG in chylomicrons, plasma LDL, HDL and total cholesterol, plasma TAG, insulin, glucose and appetite hormone levels. At the end of the test day an ad libitum meal will be served and food intake registered.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy males aged 18-40 years
- •Normal weight or moderately overweigh (BMI 25-30 kg/m2)
排除标准
- •Blood drawing/donation less than six months prior to start of the study
- •Hemoglobin concentration <8mmol/L
- •Chronic diseases (i.e. diabetes, CVD), hypertension, hyperlipidemia
- •Consumption of dietary supplements including vitamin tablets
- •Excess physical activity (>10h of intense physical activity per week)
- •Medicine use (not including occasional consumption of pain killers)
结局指标
主要结局
TAG in chylomicrons
serum TAG
HDL, LDL and total cholesterol
appetite scores
ad libium food intake
appetite hormone levels
次要结局
- free fatty acid profile
- plasma glucose
- plasma insulin
- meal macronutrient composition
- meal energy content
- meal pleasantness