Relationship Between Variations in Taste Perception and Chronic Disease Risk Factors as a Function of Age
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Sensory/hedonic rating
研究概览
简要总结
The purpose of the Taste Perception Study is to assess variations in the ability to taste and perceive sensations from various stimuli in younger (18-49 years) and older (50-85 years) volunteers. The study's goal is to determine how these sensations influence what one likes to eat, and what one chooses to eat, and whether there is an association with dietary intake, body composition and chronic disease. Another objective of the study is to determine the association between variations in oral sensations and genes mediating sensory perception and dietary behaviours.
详细描述
The objective of the Taste Perception Study is to assess variations in oral sensations in younger (18-49 years; n=35) relative to older (50-85 years; n=35) subjects, and determine the association between variations in oral sensations and measures of chronic disease risk factors, body composition, habitual dietary intake and selected genes mediating sensory perception and dietary behaviors. Subjects who are participating in the Glycemic Index study (IRB #7196) will be asked for voluntarily participation in the proposed study. These volunteers will undergo 1-2 hours of standardized testing. These tests will involve tasting or smelling certain foods/beverages or ingredients in foods/beverages and rating the degree of liking/disliking, intensity and flavor or odor using a validated general Labeled magnitude scale. Volunteers will also be asked to complete a food preference survey and eating inventory questionnaire, as well as provide a DNA sample from a cheek swab or blood sample. These data will then be merged with the measures of chronic disease risk factors, body composition and habitual dietary intake data generated from the Glycemic index study in order to better understand if variations in oral sensations influence food preferences and patterns and subsequently chronic disease risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •men and women;
- •aged 18 to 85 years old;
- •free of known chronic disease;
- •BMI < 35 kg/ m
- •Exclusion criteria:
- •BMI ≥ 35 kg/m2;
- •renal or liver disease;
- •untreated hypertension;
- •irritable bowel syndrome;
- •malabsorptive, esophageal and gastrointestinal motility disorders;
- •chronic pancreatitis, or history of acute pancreatitis within the last year;
- •hypothyroidism or hypothyroidism, as defined as screening TSH outside of normal ranges;
- •anemia, as defined by screening hematocrit of 34% for women and 38% for men;
- •smoking within the past 6 months;
- •diabetes;
- •fasting glucose ≥ 125 mg/dL;
- •pregnancy or breastfeeding;
- •history of polycystic ovary syndrome;
- •history of autoimmune or other connective tissue disorders associated with chronic inflammation, such as rheumatoid arthritis; alcohol consumption > 7 drinks/ week;
- •use of medications known to affect glucose or lipid metabolism;
- •established CVD (myocardial infarction, stroke, heart failure, coronary artery bypass, graft, stenosis > 50%, peripheral arterial disease);
- •unwillingness to adhere to study protocol;
- •weight gain or loss of more than 15 lbs within 6 months prior to enrollment and other abnormal screening laboratory analysis results.
排除标准
- 未提供
结局指标
主要结局
Sensory/hedonic rating
时间窗: 1 - 2 hours
次要结局
- Genetic Variation(1- 2 hours)