The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Irisin
研究概览
简要总结
Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.
Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who were aged between 18-65 years,
- •Patients who got diagnosed according to American College of Rheumatology criteria
- •Patients who were being followed at Firat University Department of Rheumatology
排除标准
- •Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
- •Patients who took anti-TNF treatment
- •Patients who had changes of medical treatment in last 3 months
- •Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
- •Patients who had cardiac symptoms according to New York Heart Association
- •Patients who had dysfunction that can prevent physical activity
结局指标
主要结局
Irisin
时间窗: 1 minute
Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.
次要结局
- BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho(1 minute)
研究者
Songul Baglan Yentur
Research Assistant
Firat University