Investigation of Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 71
- 试验地点
- 1
- 主要终点
- Change in hemoglobin
研究概览
简要总结
The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to altitude during exercise. This may furthermore be related to acute altitude exposure for recreational exercise use as well.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-70 years of age,
- •history of good health,
- •generally active to competitive athletes.
排除标准
- •History of cardiac or pulmonary disease,
- •not currently active,
- •unable to exercise or meet study requirements (e.g., number of sessions),
- •live at altitude (>2,100m or 7,000ft).
研究组 & 干预措施
Effect of heart rate training in simulated altitude
Participants will exercise in simulated altitude start at a minimum of 2,000ft and will increase to no greater than 16,400ft with each visit. The increase will be in accordance to maintaining >65% max heart rate during room air based maximal peak work.
干预措施: Simulated altitude (Other)
Effect of saturation of oxygen training in simulated altitude
Participants will exercise in simulated altitude start at a minimum of 2,000ft and will increase to no greater than 16,400ft with each visit. The increase will be in accordance to maintaining 40-60% of max work rate during room air work rate and based upon saturation of oxygen of between 70-80%.
干预措施: Simulated altitude (Other)
Effect of optimized training in simulated altitude
Participants will perform the more beneficial intervention (heart rate or saturation of oxygen training) to evaluate whether it improves elite athlete's training status at altitude.
干预措施: Simulated altitude (Other)
Effect of placebo training in non-simulated altitude
Participants will perform placebo beneficial intervention (heart rate or saturation of oxygen training) to evaluate whether the optimized protocol truely improves elite athlete's training status at altitude.
干预措施: Placebo simulated altitude (Other)
结局指标
主要结局
Change in hemoglobin
时间窗: Baseline, 2-week, 4-week, 6-week, and 8-week
Change in hematocrit
时间窗: Baseline, 2-week, 4-week, 6-week, and 8-week
Change in erythropoietin
时间窗: Baseline, 2-week, 4-week, 6-week, and 8-week
次要结局
- Change in peak VO2(Baseline and 6- and 8-week)
- Change in cycling performance at altitude(Baseline and 6- and 8-week)
研究者
Courtney M. Wheatley
Principal Investigator
Mayo Clinic