Cycling Induced Motor Cortex Plasticity and Functional Improvement -the Dual Task Evaluation Model for Parkinson Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Task Accuracy
研究概览
简要总结
Motor impairment in lower extremities is common in individuals with Parkinson disease (PD). Development sensitive test for early motor deviations is important. Conventional walking test cannot induce the PD related motor impairments, such as freezing of gait. Therefore, finding a safe substitute test to induce PD related motor impairments is important.
Studies showed that working memory related dual task walking was a sensitive test for PD. However, the optimal cognitive test needs to be clarified. Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking. Therefore, dual task cycling test is potential to be a safe and sensitive testing model.
Studies showed that exercise could improve cognitive function and induce brain plasticity. Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall. Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated. Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity.
The purpose of this three-year project is to develop PD-sensitive. The purposes of the first year are to translate the dual task walking test to dual task cycling test, and to establish the reliability of the dual task cycling test.
The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people.
The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity, dual task performance, and ambulation ability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of Parkinson disease.
排除标准
- •Musculoskeletal injuries on legs
- •Osteoporosis.
- •Any peripheral or central nervous system injury or disease patients.
结局指标
主要结局
Task Accuracy
时间窗: Baseline, 4 weeks and 8 weeks.
The percentage of correct responses or actions made by participants in response to walking or cycling tasks.
Reaction Time
时间窗: Baseline, 4 weeks and 8 weeks.
The duration between the onset of task start time and the participant's response to it, typically expressed in second (s).
Balance Performance
时间窗: Baseline, 4 weeks and 8 weeks
Measured by the duration the stance can be maintained, typically expressed second.
Step Length
时间窗: Baseline, 4 weeks and 8 weeks
The linear distance between the two ankles, typically expressed in centimeters(cm).
Power Spectral Density (PSD)
时间窗: Baseline, 4 weeks and 8 weeks.
Quantifies the power of EEG signals within specific frequency bands (e.g., delta, theta, alpha, beta, and gamma) over a period.
Walking Speed
时间窗: Baseline, 4 weeks and 8 weeks
The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s).
Step Time
时间窗: Baseline, 4 weeks and 8 weeks
The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds.
次要结局
- Swing Time(Baseline, 4 weeks and 8 weeks)
- Single Support Time(Baseline, 4 weeks and 8 weeks)
- Heart rate(Baseline)
- Stance Time(Baseline, 4 weeks and 8 weeks)
- Double Support Time(Baseline, 4 weeks and 8 weeks)
- Cadence(Baseline, 4 weeks and 8 weeks)
研究者
Ya-Ju Chang
Professor
Chang Gung University