Preoperative Cerebrospinal Fluid (CSF) Levels of Hypocretin and Recovery After Hip Surgery With Combined Spinal and General Anesthesia
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Anesthetic Recovery Times
研究概览
简要总结
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (18 years of age or older)
- •Male or female
- •Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic.
- •Comprehend spoken and written English
排除标准
- •ASA physical status > III (patients with severe systemic disease)
- •Diagnosed psychiatric disease (except mild depression)
- •Any diagnoses CNS disease or dementia
- •History of stroke
- •History of untreated thyroid disease
- •Difficulty in airway management (ventilation and/or intubation)
- •Body Mass Index (BMI) > 35 kg/m2
结局指标
主要结局
Anesthetic Recovery Times
时间窗: 0-72 hours after surgery
recovery from anesthesia will be measured by short-term outcomes like time to tracheal extubation and response to verbal commands, as well as by psycho-vigilance testing up to 72 hours postoperatively
次要结局
- sensitivity to sevoflurane during inhalation induction to anesthesia, determined by bispectral index of the EEG(during anesthetic induction)
- pain and sleepiness(from 0-72 hours after surgery)
研究者
Anthony Doufas
MD, PhD
Stanford University