NCT01038102已完成不适用
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance: a Randomized Controlled Study
Uppsala University2 个研究点 分布在 1 个国家目标入组 65 人开始时间: 2009年2月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Hepatic steatosis by MRT
研究概览
简要总结
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
详细描述
Specific goals:
- Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes
- Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content
- Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •abdominal obese subjects with or without type 2 diabetes
- •sagittal abdominal diameter >25cm
排除标准
- •insulin treatment
- •history of serious cardiovascular events
- •morbid obesity
- •claustrophobia (relative criterion)
结局指标
主要结局
Hepatic steatosis by MRT
时间窗: 10 weeks
次要结局
- Changes in adipose tissue gene expression and lipogenic enzyme activity(10 weeks)
- Insulin resistance by oral glucose tolerance test(10 weeks)
研究者
研究点 (2)
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