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临床试验/NCT03164200
NCT03164200已完成不适用

An Egg Based Breakfast Maintains Flexibility in Older Adults

University of Alabama at Birmingham0 个研究点目标入组 33 人开始时间: 2011年12月14日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
33
主要终点
Respiratory quotient (RQ, a measure of substrate oxidation)

研究概览

简要总结

Aging is associated with an increased risk for metabolic diseases, such as type 2 diabetes and cardiovascular disease. There is reason to believe that the time of day when specific food groups are eaten affects this risk. The investigators propose that eating foods made up of fat and protein (such as eggs) in the morning for breakfast, rather than foods made up of carbohydrates (such as white-bread toast or sugary cereal) may promote a healthier metabolism. This is because the body is designed to burn fat during times of fasting, such as overnight, during sleep. Thus, the body is not prepared to burn sugar early in the morning, when most people eat breakfast. Studies with mice have shown that a sugary breakfast meal inhibits the ability of the body to burn fat for the entire day. In contrast, a breakfast meal with more fat enabled the animals to burn fat as well as other fuels throughout the day. The ability to burn fat is thought to minimize risk for obesity, as well as related diseases such as type 2 diabetes and heart disease. The purpose of this study is to determine if, in older adult humans, consumption of a lower-carbohydrate breakfast meal (relative to a higher-carbohydrate meal) is associated with a healthier metabolism.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
None

盲法说明

Patients were randomized to either a egg breakfast or a carbohydrate breakfast

入排标准

年龄范围
55 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • • Age 55-75
  • Body mass index 24-29 kg/m2

排除标准

  • • Current practice of greater than 2h/wk of moderate intentional exercise
  • Uncontrolled diabetes
  • Unwillingness to eat study diets
  • Use of any medication known to affect metabolism
  • History of eating disorder
  • Difficulty chewing and swallowing solid food
  • Digestive diseases
  • Cognitive impairment
  • Depression
  • Recent weight change (+/- 10 lbs. in the last 12 mo.)
  • Poorly controlled blood pressure (SBP > 159 or DBP >95 mm Hg)
  • History of non-skin cancer in the last 5 y
  • Cardiovascular disease event in the past 6 mo.
  • Severe pulmonary disease
  • Renal failure
  • Major liver dysfunction (elevation of liver transaminases >3x normal in past 2 y; current/recent smoker (within 6 mo.)
  • Use of estrogen or testosterone replacement therapy
  • Current use of oral corticosteroids >5 days/month on average
  • Current use of medications for treatment of psychosis or manic-depressive illness
  • Use of weight loss medications in the previous 3 months
  • Unable to adhere to diet recommendations

结局指标

主要结局

Respiratory quotient (RQ, a measure of substrate oxidation)

时间窗: 4 weeks

24 hour respiratory quotient will be measured using whole-room indirect calorimetry

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Barbara Gower

Professor

University of Alabama at Birmingham

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