Can Exercise Training Revert and/or Minimize the Deleterious Cardiometabolic Effects of Carbohydrate Overfeeding in Individuals With and Without Increased Risk of Type 2 Diabetes?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Adipose tissue expandability
研究概览
简要总结
Low birth weight (LBW), a marker of impaired fetal growth is an independent and strong risk factor for type 2 diabetes (T2D). A western lifestyle characterized by a surplus of calories, and/or a low physical activity level, associated with increased fat storage and altered lipid metabolism plays a central role in the pathogenesis of insulin resistance and T2D. Using state-of-the-art large-scale integrative physiology studies combined with basic studies of adipose and muscle tissue stem cell functions, the investigators aim to determine if LBW individuals exhibit decreased subcutaneous adipose tissue expandability, postprandial hyperlipidaemia and ectopic fat accumulation when exposed to 4 weeks of carbohydrate overfeeding. The investigators will subsequently examine if exercise training can revert and/or minimize the deleterious effects of carbohydrate overfeeding in a possibly birth weight differential manner.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •without known disease (approved health examination)
- •caucasian
- •born at term (weeks 39-41) in Denmark
- •recruited from the national Danish Birth Registry
- •born with either low or normal birthweight (see previous)
排除标准
- •family history of diabetes in two generations (1st and 2nd degree relatives)
- •self-reported high physical activity level (>10hrs /week).
- •weight loss/gain >3 kg within the past 6 months
- •alcohol intake of more than general recommendations
- •substance abuser
- •intake of medication know to affect outcomes
研究组 & 干预措施
Low birth weight (LBW)
25 males born at term (weeks 39-41) in 1979-1981 with LBW (BW<10th percentile)
干预措施: Normal physical activity (Behavioral)
Low birth weight (LBW)
25 males born at term (weeks 39-41) in 1979-1981 with LBW (BW<10th percentile)
干预措施: High carbohydrate overfeeding (Dietary Supplement)
Low birth weight (LBW)
25 males born at term (weeks 39-41) in 1979-1981 with LBW (BW<10th percentile)
干预措施: Exercise (Behavioral)
Normal birth weight (NBW)
25 BMI- and age-matched males born at term (weeks 39-41) with normal birth weight (NBW) control individuals (BW: 50-90th percentile)
干预措施: High carbohydrate overfeeding (Dietary Supplement)
Normal birth weight (NBW)
25 BMI- and age-matched males born at term (weeks 39-41) with normal birth weight (NBW) control individuals (BW: 50-90th percentile)
干预措施: Exercise (Behavioral)
Normal birth weight (NBW)
25 BMI- and age-matched males born at term (weeks 39-41) with normal birth weight (NBW) control individuals (BW: 50-90th percentile)
干预措施: Normal physical activity (Behavioral)
结局指标
主要结局
Adipose tissue expandability
时间窗: Difference between the two groups at baseline, after 4 weeks overfeeding and after 12 weeks exercise training.
Percent (%) subcutaneous, visceral adipose tissue and hepatic fat will be determined by MR scanning in the two groups
次要结局
- Glucose turnover rate(Baseline, 4 weeks overfeeding, 12 weeks training)
- Epigenetics(Baseline, 4 weeks overfeeding, 12 weeks training)
- Lipid turnover rate(Baseline, 4 weeks overfeeding, 12 weeks training)
研究者
Charlotte Brøns
PhD
Rigshospitalet, Denmark