NCT03272152Unknown不适用
Comprehensive DNA Methylation Profiling of Inflammatory and Non-Inflammatory Mucosa in Crohn's Disease
Jinling Hospital, China1 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2017年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Intestinal inflammation under colonoscopy
研究概览
简要总结
Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Active Crohn's disease(CDAI score≥ 150)
排除标准
- •No ileal lesions
- •Under treatment of immunomodulators, biologic agents or steroids
结局指标
主要结局
Intestinal inflammation under colonoscopy
时间窗: Jan 2017 to Sep 2017
Intestinal ulcer or enteritisis observed under colonoscopy
次要结局
- CDAI(Jan 2017 to Sep 2017)
研究者
Jianan Ren
Director of General Surgery Institute
Jinling Hospital, China
研究点 (1)
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