Evolution of the Profile of Infectious Endocarditis in France in 2008
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 484
- 主要终点
- Mortality
研究概览
简要总结
Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious (20 % of deaths during hospitalization) disease . Its epidemiological profile was considerably modified these last years.New predisposing factors appeared, due to increasing number of patients wearing valvular prosthetics. The purpose of this study is to realize in 2008 a new observational study on populational basis to describe and analyze the evolution of the epidemiology of IE in France, compared to previous studies conducted in 1991 and 1999.
详细描述
It is a prospective observational study based on a population of 25 million inhabitants. The cases are recruited over a one year period, from January 1st till December 31st, 2008, in six regions of France (Rhône-Alpes, Paris et Petite Couronne, Lorraine, Franche-Comté, Marne, Languedoc-Roussillon) and in the department of Ille-et-Vilaine. The IE cases are declared by clinicians taking care of the patients, microbiologists and cardiac ultrasonographists.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major Patient
- •Supported in one of the participating centers
- •The application of diagnostic classification criteria of Duke modified by Li is carried out after collection of all the data at the output of the patient. Will be included in the observatory that patients meeting criteria for definite or possible endocarditis.
- •Affiliated with the French social security regime
排除标准
- •Patients not living in one of the studied regions
结局指标
主要结局
Mortality
时间窗: 1 year
Vital status
次要结局
- Frequency of antibiotic resistance by the germs (streptococci and staphylococci)(during the hospitalization, 1 year maximum)