Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Number of Patients Who Met and Exceeded Response Criteria of Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
研究概览
简要总结
The purpose of this study is to understand nitrous oxide effects in post traumatic stress disorder (PTSD)
详细描述
Post traumatic stress disorder (PTSD) is a disabling mental health disorder that impacts the lives of individuals. This study aims to understand nitrous oxide's effects in PTSD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18-80
- •Veterans of the United States Uniformed Services
- •primary diagnosis of PTSD
- •sufficient severity of PTSD symptoms
- •fluency in English
- •capacity to provide informed consent
排除标准
- •psychiatric or medical conditions that make participation unsafe
- •pregnant or nursing females
- •allergy to nitrous oxide
研究组 & 干预措施
Nitrous Oxide
PTSD patients in this arm will receive a single inhalation dose of 50% nitrous oxide and 50% oxygen for 1 hour
干预措施: Nitrous Oxide (Drug)
结局指标
主要结局
Number of Patients Who Met and Exceeded Response Criteria of Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
时间窗: Baseline and 1 week post inhalation
Patients given CAPS-5 (Clinician Administered PTSD Scale for DSM-5), a 30-item structured interview that can be used to assess PTSD symptoms over the past week. For the CAPS-5 the minimum units are 0 and maximum units on the total scale are 80. The higher the number on the CAPS-5, the more severe the symptoms. Response was defined as at least a 12 point reduction on the CAPS-5
次要结局
未报告次要终点
研究者
Carolyn Rodriguez
Assistant Professor
Stanford University