Effects of Nitrous Oxide: A Dose-Response Analysis
Overview
- Phase
- Not Applicable
- Intervention
- 10% N2O
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Choice of N2O vs. placebo
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This is a dose-response analysis.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Placebo + 10% N2O
0% N2O inhaled during psychomotor testing, 10% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Intervention: 10% N2O
Placebo + 20% N2O
Placebo inhaled during psychomotor testing, 20% N2O inhaled during psychomotor testing, then subject's choice of the 2.
Intervention: 20% N2O
Placebo + 30% N2O
Placebo inhaled during psychomotor testing, 30% N2O inhaled during psychomotor testing, then subject's choice of the 2.
Intervention: 30% N2O
Placebo + 40% N2O
Placebo inhaled during psychomotor testing, 40% N2O inhaled during psychomotor testing, then subject's choice of the 2.
Intervention: 40% N2O
Outcomes
Primary Outcomes
Choice of N2O vs. placebo
Time Frame: After each pair of sample tests
Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject \& the technician administering the inhalant were blinded. During each intervention and each session, subjects underwent psychomotor testing.