Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

Phase 2

Completed

• Conditions: Substance-Related Disorders; Opioid-Related Disorders
• Interventions: Drug: 30% N2O; Drug: 20% N2O; Drug: 40% N2O

• Registration Number: NCT00000249
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 1993-09
• Primary Completion: 1995-06
• Study Completion: 1995-06
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
30% N2O	30% N2O	Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
20% N2O	20% N2O	Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 \& 30 minutes
40% N2O	40% N2O	Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes

Primary Outcome Measures

Name	Time	Method
Pain intensity	during cold test at 10 min & 30 min of inhalation	Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States