Effects of Subanesthetic Concentrations of Nitrous Oxide
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- University of Chicago
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Pain intensity
Study Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 21 Years to 37 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
20% N2O
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes
Intervention: 20% N2O (Drug)
30% N2O
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Intervention: 30% N2O (Drug)
40% N2O
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Intervention: 40% N2O (Drug)
Outcomes
Primary Outcomes
Pain intensity
Time Frame: during cold test at 10 min & 30 min of inhalation
Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes
Secondary Outcomes
No secondary outcomes reported